The first habitation of the site dates from the Neolithic and Early Minoan period (3rd millenium B.C.). In the late Classical period (beginning of the 4th century B.C.) the Gortynians established the sanctuary of Asklepios at the harbour. During the tremendous earthquake of 46 B.C. the city was destroyed and subsequently rebuilt. In the Early Christian and Byzantine periods, a small settlement developed and the basilica was erected. The most important monuments of the site are:
The Temple of Asklepios., the "Treasury"., the Fountain, a large, three-aisled basilica, an Early Minoan settlement (2600-2000 B.C.), the West Stoa, the North Stoa, the Nymphaion and two large, mud-brick cisterns.