Megali Vrissi (GR: Μεγάλη Βρύση) lies 32km south of Heraklion, at 620 m above sea level.
In the Barozzi document of 1577, it is mentioned as forming part of the province of Monofatsi and, in the Archives of Megalo Kastro (Heraklion), it is quoted in 1583 as having 71 inhabitants; there is also a reference to the village in the Basilicata document of 1630. The Turkish census records it with 47 families in 1671, and in the Egyptian one in 1834, it figures with 27 families. In the censi of 1881 and 1900 it is mentioned as a municipality in its own right with, respectively, 240 inhabitants and 307 inhabitants.
As of 1928, it becomes a commune and today it counts over 900 inhabitants. Saint Constantine is the patron saint of the village.
The churches of Aghia Anna and of the Panagia Almiri are worth visiting.
The Aeolian Park, one of the islands pioneering projects, has been installed in Megali Vrisi and produces electricity of 5MW.